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Jacot Lab for Pediatric Cardiovascular Engineering Jacot Lab for Pediatric Cardiovascular Engineering Jacot Lab for Pediatric Cardiovascular Engineering
Jacot Lab for Pediatric Cardiovascular Engineering

Note

Postdoc position available. Please click here for details.

Undergraduates interested in research experience should also contact Dr. Jeff Jacot at jeff.jacot@rice.edu.

Pediatric Cardiac Bioengineering Lab Publications

 

Benavides OM, Quinn JP, Pok S, Petsche Connell J, Ruano R, Jacot JG.  Capillary-like Network Formation by Human Amniotic Fluid-Derived Stem Cells with Fibrin/Poly(Ethylene Glycol) Hydrogel. Tissue Engineering Part A. [Submitted for review]. 2014.

Pok S, Vitale F, Eichmann SL, Benavides OV, Pasquali M, Jacot J. Biocompatible Carbon Nanotube – Chitosan Cardiac Patches Matching the Electrical Conductivity of the Heart. ACS-Nano. [In Press]. 2014.

Pok S, Jacot JG. Work and Tension: New Evidence that Adherent Cells of the Same Area Do the Same Work Independent of Stiffness and Focal Adhesions. Biophysical Journal. 107.4 (2014): 798-799. 

Klouda L, Tsao C, & Jacot J, Tissue Engineering in Congenital Heart Disease. Challenges in Regenerative Medicine. 2014. 

Pok S.; Benavides O.M.; Hallal, P.; Jacot J.G. Use of myocardial matrix in a chitosan-based full-thickness heart patch. Tissue engineering Part A. (2014), 20, 1877-87. PMID 24433519

Mondy WL, Casteleyn C, van Loo D, Raja M, Singleton C & Jacot JG. Osmium Tetroxide Enhancement of Micro-CT Vascular Corrosion Cast Images for use in the Computer Aided Design of Microvasculature. Microscopy and Microanalysis. 19(6):1416-27. (2013) PMID 24103507. 

Petsche Connell J, Augustini E, Moise Jr KJ, Johnson A & Jacot JG. Formation of functional gap junctions in amniotic fluid-derived stem cells induced by neonatal rat cardiomyocytes. Journal of Cellular and Molecular Medicine. 17(6): 774-781 (2013). PMID 23634988.

Petsche Connell J, Camci-Unal G, Khademhosseini A, Jacot JG. Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications. Tissue Engineering Part B. (2013). DOI 10.1089/ten.TEB.2012.0561. PMID: 23350771.  

Pok S, Myers JD, Madihally SV & Jacot JG. In vitro evaluation of a composite patch of PCL, chitosan and gelatin for cardiac applications. Acta Biomaterialia. 9:5630-5642 (2013). PMID: 23128158.  

Benavides OM, Petsche JJ, Moise Jr KJ, Johnson A & Jacot JG. VEGF Induces Endothelial Differentiation of Amniotic Fluid-Derived Stem Cells. Tissue Engineering Part A. 18(11-12):1123-1131 (2012). PMID 22250756. 

Pok S & Jacot JG. Biomaterials advances in patches for congenital heart defect repair. Journal of Cardiovascular Translational Research. 4(5):646-54 (2011).

Jacot JG, Kita-Matsuo H, Wei K, Chen HSV, Omens JH, Mercola M, & McCulloch AD. Cardiac myocyte force development during differentiation and maturation. Annals of the New York Academy of Sciences. 1188:121-127 (2010).

Jacot JG, Martin JC & Hunt DL. Mechanobiology of cardiac differentiation and development. Journal of Biomechanics. . 43:93-98 (2010).

Kita-Matsui H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Haverlsag R, McCulloch A, Conklin B, Price JH, Chen HSV & Mercola M. Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. PLoS ONE. 4(4):e5046. (2009).

Jacot JG, Raskin AJ, Omens JH, McCulloch AD & Tung L. Mechanotransduction in Cardiac and Stem Cell Derived Cardiac Cells. Book Chapter In: Mechanosensitivity in Cells and Tissues 3rd ed.. eds. Kamkin A. & Kiseleva I. ( 2009).

Jacot JG, McCulloch AD & Omens JH. Control of the Functional Maturation of Neonatal Rat Cardiac Myocytes by Substrate Stiffness. Biophysical Journal. 95(7):3479-3487. (2008).

Jacot JG & Wong JY. Endothelial injury induces vascular smooth muscle cell proliferation in highly localized regions of a direct contact co-culture system. Cell Biochemistry and Biophysics. 52(1):37-46. (2008).

Leach JB, Brown XQ, Jacot JG, DiMilla PA & Wong JY. Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity. Journal of Neural Engineering. 4:26-34. (2007).

Owens CD, Wake N, Jacot JG, Gerhard-Herman M, Belkin M, Creager MA & Conte MS. Early biomechanical changes in lower extremity vein grafts: Distinct temporal phases of remodeling and wall stiffness. Journal of Vascular Surgery. 44(4):740-6. (2006).

Jacot JG, Dianis S, Schnall J & Wong JY. A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues. Journal of Biomedical Materials Research. 79(3):485-94. (2006).

Jacot JG, Abdullah I, Belkin M, Gerhard-Herman M, Gaccione P, Polak JF, Donaldson MC, Whittemore AD & Conte MS. Early adaptation of human lower extremity vein grafts: Wall stiffness changes accompany geometric remodeling. Journal of Vascular Surgery. 39:547 (2004).

 

Presentations and Posters

 Jacot JG. Engineered Heart Tissue Using Amniotic Fluid Stem Cells. University of Sao Paolo School of Medicine. July, 2014.

 Benavides OM, Brooks AR, Quinn JP & Jacot JG. Network Formation by Human Amniotic Fluid-Derived Stem Cells Within Fibrin/Poly(Ethylene Glycol) Hydrogels. Poster presentation at the Biomaterials Day Symposium, College Station, TX, June, 2014.

 Pok S, Stupin I, Pautler R, Annapragada A & Jacot JG. In Vivo Assessment of Engineered Patch for Reconstruction of Full-Thickness Right Ventricular Outflow Tract Defect. Poster presentation at the Biomaterials Day Symposium, College Station, TX, June, 2014.

Jacot JG. Engineered Heart Tissue For Correction Of Heart Defects. Boston University, Department of Biomedical Engineering. May, 2014.

Pok S, Stupin I, Pautler RG, Annapragada AV & Jacot JG. In vivo Assessment of Engineered patch for Reconstruction of Full-Thickness Right Ventricular Outflow Track Defect. Platform presentation at the Texas Children’s Hospital Surgical Research Day. May, 2014.

Jacot JG. Engineered Heart Tissue for Correction of Heart Defects. Georgia Tech and Emory University, Department of Biomedical Engineering. April, 2014.

Pok S, Vitale F, Pasquali M & Jacot JG. Hydrogels incorporating single walled carbon nanotubes for cardiac cell tissue engineering. Platform presentation at the Society for Biomaterials Annual Meeting. April, 2014.

Jacot JG. Amniotic Fluid Stem Cell-Derived Endothelial Cells as a Vascular Cell Source for Tissue Engineering. Platform presentation at the Society for Biological Engineering 4th International Conference on Stem Cell Engineering. March, 2014.

Jacot JG. Tissue Engineering Strategies for Correction of Congenital Heart Defects. BCM Center for Cell And Gene Therapy Seminar. January, 2014.

Jacot JG. Tissue Engineering Strategies for Correction of Congenital Heart Defects. Texas Children’s Hospital Research Seminar. January, 2014.

Adetiba O, Agrawal A, Verduzco R & Jacot JG. Liquid Crystal Elastomers for Strain Conditioning of Cardiomyocytes. Platform presentation at the Tissue Engineering and Regenerative Medicine International Society annual North American meeting. November, 2013.

Pok S & Jacot JG. Generation of a Heart Patch Using a Blend of Native Heart Matrix, Chitosan and Polycaprolactone. Platform presentation at the American Institute of Chemical Engineers annual meeting. November, 2013.

Jacot JG. Tissue Engineering Strategies for Correction of Congenital Heart Defects. Washington University, Department of Bioengineering. October, 2013.

Pok S, Benavides OM & Jacot JG. Decellularized Porcine Heart Myocardium Hydrogel for Reconstruction of Full-Thickness Right Ventricular Outflow Track Defect. Platform presentation at Biomedical Engineering Society Annual Meeting. September, 2013.

Gao Y, Ruano R & Jacot JG. Coculture with Cardiac Cells Demonstrated Cardiogenic Potential in Amniotic Fluid-Derived Stem Cells. Poster presentation at Biomedical Engineering Society Annual Meeting. September, 2013.

Benavides OM, Quinn J, Petsche Connell J, Ruano R & Jacot JG. Vascularization of Fibrin/Poly(Ethylene Glycol)-based Hydrogels using Amniotic Fluid-Derived Stem Cells. Poster presentation at Biomedical Engineering Society Annual Meeting. September, 2013.

Petsche Connell J, Augustini ED, Cheng SK, Ruano R & Jacot JG. Effect of Expansion Conditions on Stem Cell Marker Expression and Multipotency of Amniotic Fluid-derived Stem Cells. Poster presentation at Biomedical Engineering Society Annual Meeting. September, 2013.

Jacot JG. Cardiovascular Potential of Human Amniotic Fluid-Derived Stem Cells. Houston Stem Cell Club Seminar. September, 2013.

Jacot JG. Pediatric Cardiac Tissue Engineering. Platform presentation at Advances in Tissue Engineering Short Course. Houston, TX, August 2012.

Jacot JG. Carolina, School of Medicine. August, 2013.

Pok S, Benavides OM, Hallal PA & Jacot JG. Multi-layered Cardiac Patches. Poster presentation at the Gordon Research Conference on Biomaterials and Tissue Engineering. July, 2013.

Benavides OM, Quinn J & Jacot JG. Vascularization of Fibrin/Poly(Ethylene Glycol)-based Hydrogels using Amniotic Fluid-Derived Stem Cells. Poster presentation at the Gordon Research Conference on Biomaterials and Tissue Engineering. July, 2013.

Jacot JG. Growing Hearts: How Stem Cell-Derived Tissue Can Repair Infant Hearts. TEDx Rice 2013. Houston, TX. April, 2013.

Benavides OM, Quinn J & Jacot JG. Vascularization of fibrin/poly(ethylene glycol)-based hydrogels using amniotic fluid-derived stem cells. Poster presentation for Texas Biomaterials Day. March, 2013.

Pok SW, Benavidas OM, Hallal PA & Jacot JG. Decellularized porcine heart matrix / chitosan blended hydrogel as a cardiac surgical patch. Poster presentation for Texas Biomaterials Day. March, 2013.